While probably most people with scleritis are otherwise healthy, a substantial percentage (at least 30%) will have evidence of abnormalities in their immune system. Many patients who present with scleritis are being treated for autoimmune diseases such as rheumatoid arthritis and lupus.
In some cases, scleritis can be the first sign of such an illness. These patients generally have disease symptoms and feel unwell. It is important that patients with scleritis undergo blood tests for immune system abnormalities.
Many patients with scleritis will have abnormal blood tests but not have–and may never get–an actual disease. These patients benefit from regular monitoring.